Regarding N, it isn't that conserved in SARS-CoV-2. Variant-defining mutations include hotspots at the 5' end, possibly relating to gene regulation. And generally there's been denser mutation than in orf1, so N shows some signs of being under pressure.
This shouldn't be surprising. N is conserved in bat coronaviruses. Bats have bat cells. So there will be adjustments needed for N to perform optimally in human cells.
I'd say the regulatory and (in particular) pharma focus on the levels of specific antibodies is a form of weaponized Dunning–Kruger effect, belonging to the "Follow the Science" clade of social engineering. What I want to know is what fraction of each institution remains "in the know", with the rest devolving into drinking their own kool-aid.
Very clear exposé. Thank you.
Older groups are just self-selecting out of blood donation after infection. It's blatantly evident in the confidence intervals.
are tests available to distinguish S protein Ab from immunization and natural infection?
Regarding N, it isn't that conserved in SARS-CoV-2. Variant-defining mutations include hotspots at the 5' end, possibly relating to gene regulation. And generally there's been denser mutation than in orf1, so N shows some signs of being under pressure.
This shouldn't be surprising. N is conserved in bat coronaviruses. Bats have bat cells. So there will be adjustments needed for N to perform optimally in human cells.
I'd say the regulatory and (in particular) pharma focus on the levels of specific antibodies is a form of weaponized Dunning–Kruger effect, belonging to the "Follow the Science" clade of social engineering. What I want to know is what fraction of each institution remains "in the know", with the rest devolving into drinking their own kool-aid.